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Lactoferrin and necrotizing enterocolitis Sherman MPClin Perinatol 2013[Mar]; 40 (1): 79-91Lactoferrin (LF) is a multifunctional protein and a member of the transferrin family. LF and lysozyme in breast milk kill bacteria. In the stomach, pepsin digests and releases a potent peptide antibiotic called lactoferricin from native LF. The antimicrobial characteristics of LF may facilitate a healthy intestinal microbiome. LF is the major whey in human milk; its highest concentration is in colostrum. This fact highlights early feeding of colostrum and also fresh mature milk as a way to prevent necrotizing enterocolitis.|Animals[MESH]|Colostrum/immunology/*metabolism[MESH]|Enterocolitis, Necrotizing/*prevention & control/therapy[MESH]|Humans[MESH]|Infant, Newborn[MESH]|Intestine, Small/*immunology/microbiology[MESH]|Lactoferrin/immunology/*metabolism/therapeutic use[MESH]|Metagenome/immunology[MESH]|Milk, Human/chemistry/immunology/*metabolism[MESH]|Milk/metabolism[MESH]|Muramidase/immunology[MESH] |
