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Regulatory T cells use "Itch" to control asthma Chen WJ Clin Invest 2013[Nov]; 123 (11): 4576-8Regulatory T cells (Tregs) control type 2 T helper cell-mediated (Th2-mediated) lung inflammation, but the molecular mechanisms by which Tregs execute this activity remain elusive. In this issue of the JCI, Jin et al. reveal that Itch, a HECT-type E3 ubiquitin ligase in Tregs, plays a specific role in restraining Th2 cell responses. This finding has important implications for understanding the pathogenesis of allergy and asthma.|Animals[MESH]|Inflammation/*immunology[MESH]|T-Lymphocytes, Regulatory/*enzymology/*immunology[MESH]|Th2 Cells/*immunology[MESH]|Ubiquitin-Protein Ligases/*immunology[MESH] |
