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Correlates between autoantibodies to nucleolar antigens and clinical features in patients with systemic sclerosis (scleroderma) Reimer G; Steen VD; Penning CA; Medsger TA Jr; Tan EMArthritis Rheum 1988[Apr]; 31 (4): 525-32Immunofluorescence on rat liver sections was used to select high-titer antinucleolar antibodies (ANoA) in the sera of patients with systemic sclerosis (scleroderma). In 646 patients, 53 ANoA sera (8%) were identified, and of these, 46 were available in sufficient quantities for further analysis. The complex of RNA polymerase I was immunoprecipitated by 7 sera (15%), which uniformly produced punctate nucleolar staining. The PM-Scl antigen, a particle consisting of 11 polypeptides, was immunoprecipitated by 8 sera (17%), all of which displayed homogeneous nucleolar staining. A 34-kd nucleolar protein (fibrillarin) of the U3 RNP complex was positive in immunoblotting of 22 sera (48%), which characteristically produced clumpy nucleolar staining. Antibodies against RNA polymerase I were associated with diffuse scleroderma of short duration, which was characterized by a high prevalence of internal organ involvement, including renal crisis. Anti-U3 RNP antibodies had a high prevalence in men with significantly less joint involvement, compared with ANoA-negative patients. Anti-PM-Scl antibodies identified a group of scleroderma patients with a high prevalence of concomitant myositis and renal involvement.|Antibodies, Antinuclear/*analysis[MESH]|Antigens, Nuclear[MESH]|Chemical Precipitation[MESH]|Epitopes[MESH]|Fluorescent Antibody Technique[MESH]|Humans[MESH]|Nuclear Proteins/*immunology[MESH]|RNA Polymerase I/*immunology[MESH]|Ribonucleoproteins/*immunology[MESH]|Scleroderma, Systemic/*immunology[MESH] |
