Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Natural history of hepatic metastases from colorectal cancer--pathobiological pathways with clinical significance Paschos KA; Majeed AW; Bird NCWorld J Gastroenterol 2014[Apr]; 20 (14): 3719-37Colorectal cancer hepatic metastases represent the final stage of a multi-step biological process. This process starts with a series of mutations in colonic epithelial cells, continues with their detachment from the large intestine, dissemination through the blood and/or lymphatic circulation, attachment to the hepatic sinusoids and interactions with the sinusoidal cells, such as sinusoidal endothelial cells, Kupffer cells, stellate cells and pit cells. The metastatic sequence terminates with colorectal cancer cell invasion, adaptation and colonisation of the hepatic parenchyma. All these events, termed the colorectal cancer invasion-metastasis cascade, include multiple molecular pathways, intercellular interactions and expression of a plethora of chemokines and growth factors, and adhesion molecules, such as the selectins, the integrins or the cadherins, as well as enzymes including matrix metalloproteinases. This review aims to present recent advances that provide insights into these cell-biological events and emphasizes those that may be amenable to therapeutic targeting.|Apoptosis[MESH]|Cadherins/metabolism[MESH]|Cell Adhesion Molecules/metabolism[MESH]|Colorectal Neoplasms/*pathology[MESH]|Hepatic Stellate Cells/cytology[MESH]|Humans[MESH]|Kupffer Cells/pathology[MESH]|Liver Neoplasms/*secondary[MESH]|Liver/pathology[MESH]|Matrix Metalloproteinases/metabolism[MESH]|Mutation[MESH]|Neoplasm Invasiveness[MESH]|Neoplasm Metastasis[MESH]|Neovascularization, Pathologic[MESH]|Treatment Outcome[MESH] |
