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Clinical spectrum of pulmonary mucormycosis Bigby TD; Serota ML; Tierney LM Jr; Matthay MAChest 1986[Mar]; 89 (3): 435-9Pulmonary mucormycosis is an uncommon, but important, opportunistic fungal pneumonia which is often diagnosed post-mortem. This review emphasizes clinical and pathologic characteristics of pulmonary mucormycosis that differentiate this infection from other fungal pneumonias. The most common clinical presentation of pulmonary mucormycosis is a rapidly progressive pneumonia with diffuse infiltrates on chest radiographic examination of a patient with an underlying hematologic malignancy treated with immunosuppressive drugs. Other immunocompromised hosts at risk for pulmonary mucormycosis include patients with diabetes mellitus who may develop a distinctive endobronchial form of this disease. Early consideration of this diagnosis, along with aggressive diagnostic evaluation, are critical to effective therapy and patient survival. While treatment with amphotericin B is the mainstay of therapy for pulmonary mucormycosis, diabetics with endobronchial disease may benefit from early, aggressive surgical resection of the involved lung tissue.|Adult[MESH]|Diabetes Mellitus/physiopathology[MESH]|Diabetic Ketoacidosis/physiopathology[MESH]|Diagnosis, Differential[MESH]|Female[MESH]|Humans[MESH]|Lung Diseases, Fungal/diagnostic imaging/pathology/*physiopathology[MESH]|Male[MESH]|Middle Aged[MESH]|Mucormycosis/diagnostic imaging/pathology/*physiopathology[MESH]|Radiography[MESH]|Syndrome[MESH] |
