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English Wikipedia
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Lymphocyte depression by cancer Edwards AJAnn R Coll Surg Engl 1977[May]; 59 (3): 222-30We believe we have shown in the animal model that in cancer the host's lymphoreticular tissues are engaged by a systemically disseminated antilymphocytic humoral factor that destroys the T-cell-dependent pathway, allowing the dissemination of the disease that results in the death of the animal. From studies on patients with cancer there appears to be a real possibility of the presence of a similar substance in man. Such a factor may form the basis for the definiation of cancer and an explanation of cancer illness on the runt hypothesis. Moreover, if the factor could be identified and antagonized a major therapeutic advantage would be achieved.|Adenocarcinoma/immunology[MESH]|Animals[MESH]|Antibody Formation[MESH]|DNA, Neoplasm/metabolism[MESH]|Humans[MESH]|Lymphocyte Activation[MESH]|Lymphoid Tissue/immunology[MESH]|Mammary Neoplasms, Experimental/immunology[MESH]|Mice[MESH]|Mice, Inbred Strains[MESH]|Middle Aged[MESH]|Neoplasms/*immunology[MESH]|RNA, Neoplasm/metabolism[MESH]|T-Lymphocytes/*immunology[MESH] |
