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Autopsy pathology in the acquired immune deficiency syndrome Reichert CM; O'Leary TJ; Levens DL; Simrell CR; Macher AMAm J Pathol 1983[Sep]; 112 (3): 357-82The acquired immune deficiency syndrome (AIDS) is a devastating new illness which appears to be sexually and parenterally transmissible. AIDS was first described in the male homosexual community; however, the disease has more recently been described among intravenous drug abusers, Haitians, hemophiliacs, and others. The etiologic agent is unknown. AIDS may represent an infection by a previously undescribed organism, a mutant of a known microorganism, or a multifactorial combination of environmental, immunologic, and genetic factors. As a consequence of the disease's seemingly irreversible ablation of the cell-mediated immune system, AIDS victims succumb to a variety of infections and/or unusual neoplasms. In its fully developed form, mortality approaches 100%. At autopsy the gross and microscopic pathology of the syndrome can be divided into three general categories: 1) morphologic manifestations of profound lymphoid depletion; 2) infections, usually with mixed opportunistic pathogens; and 3) unusual neoplasms, most frequently Kaposi's sarcoma or high-grade lymphomas.|Acquired Immunodeficiency Syndrome/etiology/mortality/*pathology[MESH]|Adrenal Glands/pathology[MESH]|Adult[MESH]|Bone Marrow/pathology[MESH]|Child[MESH]|Cytomegalovirus Infections/complications/pathology[MESH]|Digestive System/pathology[MESH]|Female[MESH]|Herpesviridae Infections/complications/pathology[MESH]|Homosexuality[MESH]|Humans[MESH]|Liver/pathology[MESH]|Lung Diseases/etiology/pathology[MESH]|Lymph Nodes/pathology[MESH]|Middle Aged[MESH]|Neurologic Manifestations[MESH]|Pneumonia, Pneumocystis/complications/pathology[MESH]|Retinitis/etiology/pathology[MESH]|Sarcoma, Kaposi/complications/pathology[MESH]|Spleen/pathology[MESH]|Thymus Gland/pathology[MESH]|United States[MESH]|Urogenital System/pathology[MESH] |
