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Nephritogenic antibodies in MRL/lpr lupus mice: molecular characteristics in pathological and genetic aspects Itoh J; Takahashi S; Ono M; Yamamoto T; Nose M; Kyogoku MTohoku J Exp Med 1994[May]; 173 (1): 65-74MRL/lpr mice spontaneously develop a lethal glomerulonephritis (GN). We found that IgG3 production in this strain of mice has a critical role on the development of GN; 1) IgG3 levels were high in kidney-extracted IgG and in circulating IgG immune complexes (IC), 2) serum IgG3 was selectively reduced by cyclosporin A treatment, associated with amelioration of GN, and 3) the mRNA levels of IgG3 correlated well with the severity of GN among the MRL/lpr x (MRL/lpr x C3H/lpr) F1 backcross mice with the rearranged genetic profile. Based on these results, we have successfully established five hybridoma clones which produce nephritogenic IgG3 antibodies from an unmanipulated MRL/lpr mouse. When they were injected to normal mice, four of the five clones generated cell-proliferative GN associated with the marked cellular infiltrates, while the remaining clone induced wire loop-like lesions. This result suggests that particular antibodies generated in MRL/lpr mice have a different pathogenic potency. The V-region sequence study of these nephritogenic antibodies revealed that the two types of the glomerular lesions were mediated by a different B cell precursor. In conclusion, GN in MRL/lpr lupus mice is thought to be generated by the expansion of clonally different B cells producing nephritogenic antibodies with a different pathogenic potency.|Amino Acid Sequence[MESH]|Animals[MESH]|Antibodies/*immunology[MESH]|Base Sequence[MESH]|Glomerulonephritis/*genetics/*immunology/pathology[MESH]|Immunoglobulin G/genetics/immunology[MESH]|Lupus Nephritis/*immunology[MESH]|Mice[MESH]|Mice, Mutant Strains/*immunology[MESH]|Molecular Sequence Data[MESH]|RNA, Messenger/metabolism[MESH] |
