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Hereditary warfarin resistance Diab F; Feffer SSouth Med J 1994[Mar]; 87 (3): 407-9We report on a case of hereditary warfarin resistance in a 27-year-old black man. Hereditary warfarin resistance is a rare disorder transmitted as autosomal dominant. It should be suspected in patients who require high doses of warfarin, achieve high plasma warfarin levels, and have a normal plasma warfarin clearance. Treatment includes either high dose warfarin or heparin (subcutaneous).|*Genes, Dominant[MESH]|Adult[MESH]|Drug Resistance/*genetics[MESH]|Heparin/administration & dosage[MESH]|Humans[MESH]|Male[MESH]|Prothrombin Time[MESH]|Thrombophlebitis/blood/*drug therapy[MESH]|Vitamin K/physiology[MESH]|Warfarin/administration & dosage/pharmacokinetics/*pharmacology[MESH] |
