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Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy Meshnick SR; Taylor TE; Kamchonwongpaisan SMicrobiol Rev 1996[Jun]; 60 (2): 301-15Artemisinin and its derivatives are endoperoxide-containing compounds which represent a promising new class of antimalarial drugs. In the presence of intraparasitic iron, these drugs are converted into free radicals and other electrophilic intermediates which then alkylate specific malaria target proteins. Combinations of available derivatives and other antimalarial agents show promise both as first-line agents and in the treatment of severe disease.|*Artemisinins[MESH]|Animals[MESH]|Antimalarials/metabolism/pharmacology/*therapeutic use[MESH]|Clinical Trials as Topic[MESH]|Drug Resistance[MESH]|Humans[MESH]|Malaria, Falciparum/*drug therapy[MESH]|Malaria/*drug therapy[MESH]|Peroxides/metabolism/pharmacology/*therapeutic use/toxicity[MESH]|Plasmodium falciparum/drug effects[MESH]|Sesquiterpenes/metabolism/pharmacology/*therapeutic use/toxicity[MESH] |
