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Interleukin-6 in the injured patient Marker of injury or mediator of inflammation?Biffl WL; Moore EE; Moore FA; Peterson VMAnn Surg 1996[Nov]; 224 (5): 647-64OBJECTIVE: The effects of interleukin (IL)-6 in the injured patient are examined in an attempt to clarify the potential pathophysiologic role of IL-6 in the response to injury. SUMMARY BACKGROUND DATA: Interleukin-6 is an integral cytokine mediator of the acute phase response to injury and infection. However, prolonged and excessive elevations of circulating IL-6 levels in patients after trauma, burns, and elective surgery have been associated with complications and mortality. The mechanistic role of IL-6 in mediating these effects is unclear. METHODS: A review of current literature is performed to summarize the origins, mechanisms of action, and biologic effects of IL-6 and to characterize the IL-6 response to injury. RESULTS: Interleukin-6 is a multifunctional cytokine expressed by a variety of cells after a multitude of stimuli, under complex regulatory control mechanisms. The IL-6 response to injury is uniquely consistent and related to the magnitude of the insult. Moreover, the early postinjury IL-6 response correlates with complications as well as mortality. CONCLUSIONS: Interleukin-6 appears to play an active role in the postinjury immune response, making it an attractive therapeutic target in attempts to control hyperinflammatory provoked organ injury.|Antigens, CD/physiology[MESH]|Biomarkers[MESH]|Burns/immunology[MESH]|Cytokines/physiology[MESH]|Humans[MESH]|Immune Tolerance[MESH]|Inflammation/immunology[MESH]|Interleukin-6/biosynthesis/blood/*physiology[MESH]|Receptors, Interleukin-6[MESH]|Receptors, Interleukin/physiology[MESH]|Signal Transduction[MESH]|Surgical Procedures, Operative[MESH]|Wounds and Injuries/*immunology/mortality[MESH] |
