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Acute myeloid leukaemia Stevens RFBr Med Bull 1996[Oct]; 52 (4): 764-77There has been considerable progress in the understanding and treatment of childhood acute myeloid leukaemia over the past two decades. In particular, cyto- and molecular genetics offer the potential for more specific diagnosis of what is basically a heterogeneous disease. To date treatment has been based on a steady increase in cytotoxic chemotherapy with or without the addition of bone marrow transplantation. Randomised therapeutic trials are difficult to perform in what is a rare disease. The best way forward is for paediatric trial groups worldwide to collaborate in developing common, or parallel, therapeutic protocols.|Acute Disease[MESH]|Bone Marrow Transplantation[MESH]|Child[MESH]|Child, Preschool[MESH]|Drug Resistance, Multiple[MESH]|Drug Resistance, Neoplasm[MESH]|Humans[MESH]|Infant[MESH]|Infant, Newborn[MESH]|Leukemia, Myeloid/diagnosis/genetics/*therapy[MESH]|Recurrence[MESH]|Remission Induction[MESH] |
