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Alpha adrenoceptor blockade in the treatment of benign prostatic hyperplasia: past, present and future Kirby RS; Pool JLBr J Urol 1997[Oct]; 80 (4): 521-32The treatment of BPH by alpha blockade is built upon a sound anatomical, physiological and pharmacological rationale. The theory is borne out in clinical practice; alpha adrenoceptor antagonists have been shown in placebo-controlled studies to improve symptoms of BPH and increase urinary flow rate. In hypertensive patients, there is a clinically significant reduction in blood pressure, with little or no effect on the blood pressure of normotensive patients with BPH. The development of selective alpha-1 adrenoceptor antagonists with a gradual onset and long duration of action has improved the tolerability and makes this class of drug a valuable alternative to surgery in many cases. Further refinements in the selectivity of alpha-1 adrenoceptor antagonists may enable even better targeted alpha blockade for BPH in the future by specific antagonism of the alpha-1 A adrenoceptor, although this hypothesis has yet to be confirmed clinically.|Adrenergic alpha-Antagonists/adverse effects/chemistry/*therapeutic use[MESH]|Blood Pressure/drug effects[MESH]|Decision Making[MESH]|Drug Therapy, Combination[MESH]|Humans[MESH]|Hypertension/chemically induced[MESH]|Male[MESH]|Patient Selection[MESH]|Prostatic Hyperplasia/*drug therapy[MESH]|Sexual Dysfunction, Physiological/chemically induced[MESH] |
