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Unconventional myosins in cell movement, membrane traffic, and signal transduction Mermall V; Post PL; Mooseker MSScience 1998[Jan]; 279 (5350): 527-33In the past few years genetic, biochemical, and cytolocalization data have implicated members of the myosin superfamily of actin-based molecular motors in a variety of cellular functions including membrane trafficking, cell movements, and signal transduction. The importance of myosins is illustrated by the identification of myosin genes as targets for disease-causing mutations. The task at hand is to decipher how the multitude of myosins function at both the molecular and cellular level-a task facilitated by our understanding of myosin structure and function in muscle.|*Cell Movement[MESH]|*Signal Transduction[MESH]|Animals[MESH]|Cell Membrane/*metabolism[MESH]|Hearing[MESH]|Humans[MESH]|Models, Biological[MESH]|Mutation[MESH]|Myosins/chemistry/genetics/*physiology[MESH]|Organelles/*physiology[MESH]|Vision, Ocular[MESH] |
