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Cowden s disease--a report on the first case in Korea and literature review Lee HR; Moon YS; Yeom CH; Kim KW; Chun JY; Kim HK; Choi HS; Kim DK; Chung TSJ Korean Med Sci 1997[Dec]; 12 (6): 570-5Cowden's disease, or multiple hamartoma syndrome, is an uncommon condition with characteristic mucocutaneous lesions associated with abnormalities of the breast, thyroid, and gastrointestinal tract. We describe a 32-year-old man with oral mucosal papillomatosis and plantar hyperkeratosis as a definite case of Cowden's disease according to the criteria proposed by Salem and Steck. The patient also had a thyroid mass and numerous gastrointestinal polyps endoscopically. Histologically the polyps were hamartomatous or hyperplastic polyps. The oral papillary lesions were fibroepithelial polyps and the thyroid mass was a follicular adenoma. We review the literature on this entity and summarize the pertinent findings. To the best of our knowledge, this is the first documented case of Cowden's disease in a Korean.|Adult[MESH]|Hamartoma Syndrome, Multiple/*diagnosis/epidemiology[MESH]|Humans[MESH]|Incidence[MESH]|Intestinal Polyps/pathology[MESH]|Keratoderma, Palmoplantar/pathology[MESH]|Korea/epidemiology[MESH]|Male[MESH]|Papilloma/pathology[MESH]|Thyroid Neoplasms/pathology[MESH]|Tongue Neoplasms/pathology[MESH] |
