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l�ll Adaptive mutation: has the unicorn landed?Foster PLGenetics 1998[Apr]; 148 (4): 1453-9Reversion of an episomal Lac- allele during lactose selection has been studied as a model for adaptive mutation. Although recent results show that the mutations that arise during selection are not "adaptive" in the original sense, the mutagenic mechanism that produces these mutations may nonetheless be of evolutionary significance. In addition, a transient mutational state induced in a subpopulation of starving cells could provide a species with a mechanism for adaptive evolution.|*Mutation[MESH]|Adaptation, Biological/*genetics[MESH]|Biological Evolution[MESH]|Escherichia coli/genetics[MESH]|Lac Operon/genetics[MESH]|Models, Genetic[MESH]|Rec A Recombinases/genetics[MESH]|Selection, Genetic[MESH] |