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The diagnosis of Clostridium difficile-associated disease Brazier JSJ Antimicrob Chemother 1998[May]; 41 Suppl C (ä): 29-40There are well-documented risk factors associated with the development of antibiotic-associated diarrhoea; knowledge of these and of the typical signs and symptoms should alert the clinician to the possibility of Clostridium difficile-associated diarrhoea (CDAD). It is therefore common practice in large general hospitals for clinicians to request, and for laboratories to include, investigations for C. difficile on in-patient stool specimens to confirm a diagnosis of CDAD. The laboratory methods used to investigate for CDAD are divided into two main categories: those that are aimed at detecting the presence of C. difficile or its products, and those that detect either of its two major toxins, A (enterotoxin) and B (cytotoxin). Within each of these broad strategies there are various rationales which are reviewed here.|*Clostridioides difficile[MESH]|Animals[MESH]|Diarrhea/*diagnosis/*microbiology[MESH]|Enterocolitis, Pseudomembranous/*diagnosis/*microbiology[MESH]|Humans[MESH] |
