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B Vitamin deficiency and neuropsychiatric syndromes in alcohol misuse Cook CC; Hallwood PM; Thomson ADAlcohol Alcohol 1998[Jul]; 33 (4): 317-36Alcohol misuse and alcohol withdrawal are associated with a variety of neuropsychiatric syndromes, some of which are associated with significant morbidity and mortality. B vitamin deficiency is known to contribute to the aetiology of a number of these syndromes, and B vitamin supplementation thus plays a significant part in prophylaxis and treatment. In particular, the Wernicke Korsakoff syndrome (WKS). due to thiamine deficiency, is a common condition in association with alcohol misuse, and is associated with high morbidity and mortality. Nicotinamide deficiency may result in a rarer condition, alcoholic pellagra encephalopathy, which often has a similar clinical presentation to WKS. This review considers the role of B vitamins in the aetiology and treatment of neuropsychiatric syndromes associated with alcohol misuse, with particular emphasis on WKS.|Alcohol Amnestic Disorder/etiology/therapy[MESH]|Humans[MESH]|Pellagra/etiology/therapy[MESH]|Psychoses, Alcoholic/*etiology/*therapy[MESH]|Thiamine Deficiency/complications/therapy[MESH]|Vitamin B 6 Deficiency/complications/therapy[MESH]|Vitamin B Deficiency/*complications/*therapy[MESH]|Wernicke Encephalopathy/etiology/therapy[MESH] |
