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10.1074/jbc.M115.704395 http://scihub22266oqcxt.onion/10.1074/jbc.M115.704395 C4825001!4825001!26817846     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26817846&cmd=llinks): Failed to open stream: HTTP request failed! 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A ?Love? Dart Allohormone Identified in the Mucous Glands of Hermaphroditic Land Snails* |pdf=|usr=}}{{26817846}} gab.com Text A Love Dart Allohormone Identified in the Mucous Glands of Hermaphroditic Land Snails* JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26817846 #FOAvip Animals have evolved many ways to enhance their own reproductive success. One bizarre sexual ritual is the ?love? dart shooting of helicid snails, which has courted many theories regarding its precise function. Acting as a hypodermic needle, the dart transfers an allohormone that increases paternity success. Its precise physiological mechanism of action within the recipient snail is to close off the entrance to the sperm digestion organ via a contraction of the copulatory canal, thereby delaying the digestion of most donated sperm. In this study, we used the common garden snail Cornu aspersum to identify the allohormone that is responsible for this physiological change in the female system of this simultaneous hermaphrodite. The love dart allohormone (LDA) was isolated from extracts derived from mucous glands that coat the dart before it is stabbed through the partner's body wall. We isolated LDA from extracts using bioassay-guided contractility measurement of the copulatory canal. LDA is encoded within a 235-amino acid precursor protein containing multiple cleavage sites that, when cleaved, releases multiple bioactive peptides. Synthetic LDA also stimulated copulatory canal contractility. Combined with our finding that the protein amino acid sequence resembles previously described molluscan buccalin precursors, this indicates that LDA is partially conserved in helicid snails and less in other molluscan species. In summary, our study provides the full identification of an allohormone that is hypodermically injected via a love dart. More importantly, our findings have important consequences for understanding reproductive biology and the evolution of alternative reproductive strategies. Twit Text FOAVip A Love Dart Allohormone Identified in the Mucous Glands of Hermaphroditic Land Snails* ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26817846 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26817846 #FOAvip English Wikipedia <ref>{{Cite pmid|26817846}}</ref> A ?Love? Dart Allohormone Identified in the Mucous Glands of Hermaphroditic Land Snails* #MMPMID26817846 Stewart MJ; Wang T; Koene JM; Storey KB; Cummins SF J Biol Chem 2016[Apr]; 291 (15): 7938-50 PMID26817846show ga Animals have evolved many ways to enhance their own reproductive success. One bizarre sexual ritual is the ?love? dart shooting of helicid snails, which has courted many theories regarding its precise function. Acting as a hypodermic needle, the dart transfers an allohormone that increases paternity success. Its precise physiological mechanism of action within the recipient snail is to close off the entrance to the sperm digestion organ via a contraction of the copulatory canal, thereby delaying the digestion of most donated sperm. In this study, we used the common garden snail Cornu aspersum to identify the allohormone that is responsible for this physiological change in the female system of this simultaneous hermaphrodite. The love dart allohormone (LDA) was isolated from extracts derived from mucous glands that coat the dart before it is stabbed through the partner's body wall. We isolated LDA from extracts using bioassay-guided contractility measurement of the copulatory canal. LDA is encoded within a 235-amino acid precursor protein containing multiple cleavage sites that, when cleaved, releases multiple bioactive peptides. Synthetic LDA also stimulated copulatory canal contractility. Combined with our finding that the protein amino acid sequence resembles previously described molluscan buccalin precursors, this indicates that LDA is partially conserved in helicid snails and less in other molluscan species. In summary, our study provides the full identification of an allohormone that is hypodermically injected via a love dart. More importantly, our findings have important consequences for understanding reproductive biology and the evolution of alternative reproductive strategies. �A ?Love? Dart Allohormone Identified in the Mucous Glands of Hermaphro(epmc).pdf DeepDyve Pubget Overpricing