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10.1016/j.molcel.2016.06.031 http://scihub22266oqcxt.onion/10.1016/j.molcel.2016.06.031 C5893147!5893147!27477908     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27477908.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell 2016 ; 63 (3): 397-407 Nephropedia Template TP {{tp|p=27477908|t=2016. A Long Noncoding RNA Regulates Sister Chromatid Cohesion |pdf=|usr=}}{{27477908}} gab.com Text A Long Noncoding RNA Regulates Sister Chromatid Cohesion JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=27477908 #FOAvip Long noncoding RNAs (lncRNAs) are involved in diverse cellular processes through multiple mechanisms. Here, we describe a previously uncharacterized human lncRNA, CONCR (cohesion regulator noncoding RNA), that is transcriptionally activated by MYC and is upregulated in multiple cancer types. The expression of CONCR is cell cycle regulated, and it is required for cell-cycle progression and DNA replication. Moreover, cells depleted of CONCR show severe defects in sister chromatid cohesion, suggesting an essential role for CONCR in cohesion establishment during cell division. CONCR interacts with and regulates the activity of DDX11, a DNA-dependent ATPase and helicase involved in DNA replication and sister chromatid cohesion. These findings unveil a direct role for an lncRNA in the establishment of sister chromatid cohesion by modulating DDX11 enzymatic activity. Twit Text FOAVip A Long Noncoding RNA Regulates Sister Chromatid Cohesion ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=27477908 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27477908 #FOAvip English Wikipedia <ref>{{Cite pmid|27477908}}</ref> A Long Noncoding RNA Regulates Sister Chromatid Cohesion #MMPMID27477908 Marchese FP; Grossi E; Marín-Béjar O; Bharti SK; Raimondi I; González J; Martínez-Herrera DJ; Athie A; Amadoz A; Brosh RM; Huarte M Mol Cell 2016[Aug]; 63 (3): 397-407 PMID27477908show ga Long noncoding RNAs (lncRNAs) are involved in diverse cellular processes through multiple mechanisms. Here, we describe a previously uncharacterized human lncRNA, CONCR (cohesion regulator noncoding RNA), that is transcriptionally activated by MYC and is upregulated in multiple cancer types. The expression of CONCR is cell cycle regulated, and it is required for cell-cycle progression and DNA replication. Moreover, cells depleted of CONCR show severe defects in sister chromatid cohesion, suggesting an essential role for CONCR in cohesion establishment during cell division. CONCR interacts with and regulates the activity of DDX11, a DNA-dependent ATPase and helicase involved in DNA replication and sister chromatid cohesion. These findings unveil a direct role for an lncRNA in the establishment of sister chromatid cohesion by modulating DDX11 enzymatic activity. äA Long Noncoding RNA Regulates Sister Chromatid Cohesion (epmc).pdf DeepDyve Pubget Overpricing