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10.4137/JEN.S25100 http://scihub22266oqcxt.onion/10.4137/JEN.S25100 C4768941!4768941!26949341     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26949341.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Exp+Neurosci 2016 ; 10 (ä): 31-8 Nephropedia Template TP {{tp|p=26949341|t=2016. A Simple Model to Study Tau Pathology |pdf=|usr=}}{{26949341}} gab.com Text A Simple Model to Study Tau Pathology JO: J Exp Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=26949341 #FOAvip Tau proteins play a role in the stabilization of microtubules, but in pathological conditions, tauopathies, tau is modified by phosphorylation and can aggregate into aberrant aggregates. These aggregates could be toxic to cells, and different cell models have been used to test for compounds that might prevent these tau modifications. Here, we have used a cell model involving the overexpression of human tau in human embryonic kidney 293 cells. In human embryonic kidney 293 cells expressing tau in a stable manner, we have been able to replicate the phosphorylation of intracellular tau. This intracellular tau increases its own level of phosphorylation and aggregates, likely due to the regulatory effect of some growth factors on specific tau kinases such as GSK3. In these conditions, a change in secreted tau was observed. Reversal of phosphorylation and aggregation of tau was found by the use of lithium, a GSK3 inhibitor. Thus, we propose this as a simple cell model to study tau pathology in nonneuronal cells due to their viability and ease to work with. Twit Text FOAVip A Simple Model to Study Tau Pathology ????J Exp Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=26949341 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26949341 #FOAvip English Wikipedia <ref>{{Cite pmid|26949341}}</ref> A Simple Model to Study Tau Pathology #MMPMID26949341 Houck AL; Hernández F; Ávila J J Exp Neurosci 2016[]; 10 (ä): 31-8 PMID26949341show ga Tau proteins play a role in the stabilization of microtubules, but in pathological conditions, tauopathies, tau is modified by phosphorylation and can aggregate into aberrant aggregates. These aggregates could be toxic to cells, and different cell models have been used to test for compounds that might prevent these tau modifications. Here, we have used a cell model involving the overexpression of human tau in human embryonic kidney 293 cells. In human embryonic kidney 293 cells expressing tau in a stable manner, we have been able to replicate the phosphorylation of intracellular tau. This intracellular tau increases its own level of phosphorylation and aggregates, likely due to the regulatory effect of some growth factors on specific tau kinases such as GSK3. In these conditions, a change in secreted tau was observed. Reversal of phosphorylation and aggregation of tau was found by the use of lithium, a GSK3 inhibitor. Thus, we propose this as a simple cell model to study tau pathology in nonneuronal cells due to their viability and ease to work with. äA Simple Model to Study Tau Pathology (epmc).pdf DeepDyve Pubget Overpricing