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10.1146/annurev-neuro-071013-014317 http://scihub22266oqcxt.onion/10.1146/annurev-neuro-071013-014317 C4659514!4659514!24821430     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24821430&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24821430.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Annu+Rev+Neurosci 2014 ; 37 (�): 137-59 Nephropedia Template TP {{tp|p=24821430|t=2014. A Mitocentric View of Parkinson?s Disease |pdf=|usr=}}{{24821430}} gab.com Text A Mitocentric View of Parkinson s Disease JO: Annu Rev Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=24821430 #FOAvip Parkinson?s disease (PD) is a common neurodegenerative disease, yet the underlying causative molecular mechanisms are ill defined. Numerous observations based on drug studies and mutations in genes that cause PD point to a complex set of rather subtle mitochondrial defects that may be causative. Indeed, intensive investigation of these genes in model organisms has revealed roles in the electron transport chain, mitochondrial protein homeostasis, mitophagy, and the fusion and fission of mitochondria. Here, we attempt to synthesize results from experimental studies in diverse systems to define the precise function of these PD genes, as well as their interplay with other genes that affect mitochondrial function. We propose that subtle mitochondrial defects in combination with other insults trigger the onset and progression of disease, in both familial and idiopathic PD. Twit Text FOAVip A Mitocentric View of Parkinson s Disease ????Annu Rev Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=24821430 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24821430 #FOAvip English Wikipedia <ref>{{Cite pmid|24821430}}</ref> A Mitocentric View of Parkinson?s Disease #MMPMID24821430 Haelterman NA; Yoon WH; Sandoval H; Jaiswal M; Shulman JM; Bellen HJ Annu Rev Neurosci 2014[]; 37 (�): 137-59 PMID24821430show ga Parkinson?s disease (PD) is a common neurodegenerative disease, yet the underlying causative molecular mechanisms are ill defined. Numerous observations based on drug studies and mutations in genes that cause PD point to a complex set of rather subtle mitochondrial defects that may be causative. Indeed, intensive investigation of these genes in model organisms has revealed roles in the electron transport chain, mitochondrial protein homeostasis, mitophagy, and the fusion and fission of mitochondria. Here, we attempt to synthesize results from experimental studies in diverse systems to define the precise function of these PD genes, as well as their interplay with other genes that affect mitochondrial function. We propose that subtle mitochondrial defects in combination with other insults trigger the onset and progression of disease, in both familial and idiopathic PD. �A Mitocentric View of Parkinson?s Disease (epmc).pdf DeepDyve Pubget Overpricing