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10.1016/j.molcel.2015.03.019 http://scihub22266oqcxt.onion/10.1016/j.molcel.2015.03.019 C4427526!4427526!25891074     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25891074.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell 2015 ; 58 (3): 431-9 Nephropedia Template TP {{tp|p=25891074|t=2015. A Role for REP Sequences in Regulating Translation |pdf=|usr=}}{{25891074}} gab.com Text A Role for REP Sequences in Regulating Translation JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25891074 #FOAvip REP sequences are highly structured elements found downstream of ~500 genes in Escherichia coli that result in extensive stem-loop structures in their mRNAs. However, their physiological role has remained elusive. Here, we show that REP sequences can down-regulate translation, but only if they are within 15 nt of a termination codon; a spacing of 16 nt has no effect suggesting that the REP element acts to stall ribosome movement. Ribosome stalling leads to cleavage of the mRNA and induction of the trans-translation process. Using nrdAB as a model, we find that its regulation can be partially reversed by overexpression of RNA helicases, and can be fully overcome upon UV stress, emphasizing the importance of this regulatory process. Since 50% of REP-associated genes have these elements within the critical 15 nt, these findings identify a regulatory mechanism with the potential to affect translation from a large number of genes. Twit Text FOAVip A Role for REP Sequences in Regulating Translation ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25891074 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25891074 #FOAvip English Wikipedia <ref>{{Cite pmid|25891074}}</ref> A Role for REP Sequences in Regulating Translation #MMPMID25891074 Liang W; Rudd KE; Deutscher MP Mol Cell 2015[May]; 58 (3): 431-9 PMID25891074show ga REP sequences are highly structured elements found downstream of ~500 genes in Escherichia coli that result in extensive stem-loop structures in their mRNAs. However, their physiological role has remained elusive. Here, we show that REP sequences can down-regulate translation, but only if they are within 15 nt of a termination codon; a spacing of 16 nt has no effect suggesting that the REP element acts to stall ribosome movement. Ribosome stalling leads to cleavage of the mRNA and induction of the trans-translation process. Using nrdAB as a model, we find that its regulation can be partially reversed by overexpression of RNA helicases, and can be fully overcome upon UV stress, emphasizing the importance of this regulatory process. Since 50% of REP-associated genes have these elements within the critical 15 nt, these findings identify a regulatory mechanism with the potential to affect translation from a large number of genes. äA Role for REP Sequences in Regulating Translation (epmc).pdf DeepDyve Pubget Overpricing