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10.1007/978-3-540-89615-9_15 http://scihub22266oqcxt.onion/10.1007/978-3-540-89615-9_15 C6027627!6027627!19639291     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\19639291.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Handb+Exp+Pharmacol 2009 ; ä (193): 443-70 Nephropedia Template TP {{tp|p=19639291|t=2009. Adenosine Receptors and the Kidney |pdf=|usr=}}{{19639291}} gab.com Text Adenosine Receptors and the Kidney JO: Handb Exp Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=19639291 #FOAvip The autacoid, adenosine, is present in the normoxic kidney and generated in the cytosol as well as at extracellular sites. The rate of adenosine formation is enhanced when the rate of ATP hydrolysis prevails over the rate of ATP synthesis during increased tubular transport work or during oxygen deficiency. Extracellular adenosine acts on adenosine receptor subtypes (A1, A2A, A2B, and A3) in the cell membranes to affect vascular and tubular functions. Adenosine lowers glomerular filtration rate by constricting afferent arterioles, especially in superficial nephrons, and thus lowers the salt load and transport work of the kidney consistent with the concept of metabolic control of organ function. In contrast, it leads to vasodilation in the deep cortex and the semihypoxic medulla, and exerts differential effects on NaCl transport along the tubular and collecting duct system. These vascular and tubular effects point to a prominent role of adenosine and its receptors in the intrarenal metabolic regulation of kidney function, and, together with its role in inflammatory processes, form the basis for potential therapeutic approaches in radiocontrast media-induced acute renal failure, ischemia reperfusion injury, and in patients with cardiorenal failure. Twit Text FOAVip Adenosine Receptors and the Kidney ????Handb Exp Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=19639291 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19639291 #FOAvip English Wikipedia <ref>{{Cite pmid|19639291}}</ref> Adenosine Receptors and the Kidney #MMPMID19639291 Vallon V; Osswald H Handb Exp Pharmacol 2009[]; ä (193): 443-70 PMID19639291show ga The autacoid, adenosine, is present in the normoxic kidney and generated in the cytosol as well as at extracellular sites. The rate of adenosine formation is enhanced when the rate of ATP hydrolysis prevails over the rate of ATP synthesis during increased tubular transport work or during oxygen deficiency. Extracellular adenosine acts on adenosine receptor subtypes (A1, A2A, A2B, and A3) in the cell membranes to affect vascular and tubular functions. Adenosine lowers glomerular filtration rate by constricting afferent arterioles, especially in superficial nephrons, and thus lowers the salt load and transport work of the kidney consistent with the concept of metabolic control of organ function. In contrast, it leads to vasodilation in the deep cortex and the semihypoxic medulla, and exerts differential effects on NaCl transport along the tubular and collecting duct system. These vascular and tubular effects point to a prominent role of adenosine and its receptors in the intrarenal metabolic regulation of kidney function, and, together with its role in inflammatory processes, form the basis for potential therapeutic approaches in radiocontrast media-induced acute renal failure, ischemia reperfusion injury, and in patients with cardiorenal failure. äAdenosine Receptors and the Kidney (epmc).pdf DeepDyve Pubget Overpricing