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10.1038/nrrheum.2014.198 http://scihub22266oqcxt.onion/10.1038/nrrheum.2014.198 C4346500!4346500!25422000     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25422000.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Rev+Rheumatol 2015 ; 11 (3): 189-94 Nephropedia Template TP {{tp|p=25422000|t=2015. Alternative pathways of osteoclastogenesis in inflammatory arthritis |pdf=|usr=}}{{25422000}} gab.com Text Alternative pathways of osteoclastogenesis in inflammatory arthritis JO: Nat Rev Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=25422000 #FOAvip Osteoclasts are cells of haematopoietic origin that are uniquely specialized to degrade bone. Under physiological conditions, the osteoclastogenesis pathway depends on macrophage colony-stimulating factor 1 (CSF-1, also known as M-CSF) and receptor activator of nuclear factor ?B ligand (RANKL). However, an emerging hypothesis is that alternative pathways of osteoclast generation might be active during inflammatory arthritis. In this Perspectives article, we summarize the physiological pathway of osteoclastogenesis and then focus on experimental findings that support the hypothesis that infiltrating inflammatory cells and the cytokine milieu provide multiple routes to bone destruction. The precise identity of osteoclast precursor(s) is not yet known. We propose that myeloid cell differentiation during inflammation could be an important contributor to the differentiation of osteoclast populations and their associated pathologies. Understanding the dynamics of osteoclast differentiation in inflammatory arthritis is crucial for the development of therapeutic strategies for inflammatory joint disease in children and adults. Twit Text FOAVip Alternative pathways of osteoclastogenesis in inflammatory arthritis ????Nat Rev Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=25422000 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25422000 #FOAvip English Wikipedia <ref>{{Cite pmid|25422000}}</ref> Alternative pathways of osteoclastogenesis in inflammatory arthritis #MMPMID25422000 Adamopoulos IE; Mellins ED Nat Rev Rheumatol 2015[Mar]; 11 (3): 189-94 PMID25422000show ga Osteoclasts are cells of haematopoietic origin that are uniquely specialized to degrade bone. Under physiological conditions, the osteoclastogenesis pathway depends on macrophage colony-stimulating factor 1 (CSF-1, also known as M-CSF) and receptor activator of nuclear factor ?B ligand (RANKL). However, an emerging hypothesis is that alternative pathways of osteoclast generation might be active during inflammatory arthritis. In this Perspectives article, we summarize the physiological pathway of osteoclastogenesis and then focus on experimental findings that support the hypothesis that infiltrating inflammatory cells and the cytokine milieu provide multiple routes to bone destruction. The precise identity of osteoclast precursor(s) is not yet known. We propose that myeloid cell differentiation during inflammation could be an important contributor to the differentiation of osteoclast populations and their associated pathologies. Understanding the dynamics of osteoclast differentiation in inflammatory arthritis is crucial for the development of therapeutic strategies for inflammatory joint disease in children and adults. äAlternative pathways of osteoclastogenesis in inflammatory arthritis (epmc).pdf DeepDyve Pubget Overpricing