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An endoscopic wireless gastrostimulator (with video) #MMPMID22248609
Deb S; Tang SJ; Abell TL; Rao S; Huang WD; To SF; Lahr C; Chiao JC
Gastrointest Endosc 2012[Feb]; 75 (2): 411-415.e1 PMID22248609show ga
Background: Gastric electric stimulation (GES) at a high-frequency, low-energy setting is an option for treating refractory gastroparesis. The currently available commercial stimulator, the Enterra neurostimulator (Medtronic Inc, Minneapolis, MN), however, requires surgical implantation and is powered by a nonrechargeable battery. Objective: To develop and test a miniature wireless GES device for endoscopic implantation in an experimental model. Design: In-vivo gastric signals were recorded and measured in a nonsurvival swine model (n = 2; 110-lb animals). Intervention: An endoscopically placed, wireless GES device was inserted into the stomach through an overtube; the two GES electrodes were endoscopically attached to the gastric mucosa and secured with endoclips to permit stimulation. Main Outcome Measurements: Stable electrogastrogram measures were observed during GES stimulation. Results: Electrogastrogram recordings demonstrated that gastric slow waves became more regular and of constant amplitudes when stomach tissues were stimulated, in comparison with no stimulation. The frequency-to-amplitude ratio also changed significantly with stimulation. Limitation: Nonsurvival pig studies. Conclusion: Gastric electric stimulation is feasible by our endoscopically implanted, wireless GES device.