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10.1038/nrmicro3569 http://scihub22266oqcxt.onion/10.1038/nrmicro3569 C5426118!5426118!26411297     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26411297&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26411297.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Rev+Microbiol 2015 ; 13 (11): 722-36 Nephropedia Template TP {{tp|p=26411297|t=2015. An updated evolutionary classification of CRISPR?Cas systems |pdf=|usr=}}{{26411297}} gab.com Text An updated evolutionary classification of CRISPR Cas systems JO: Nat Rev Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=26411297 #FOAvip The evolution of CRISPR?cas loci, which encode adaptive immune systems in archaea and bacteria, involves rapid changes, in particular numerous rearrangements of the locus architecture and horizontal transfer of complete loci or individual modules. These dynamics complicate straightforward phylogenetic classification, but here we present an approach combining the analysis of signature protein families and features of the architecture of cas loci that unambiguously partitions most CRISPR?cas loci into distinct classes, types and subtypes. The new classification retains the overall structure of the previous version but is expanded to now encompass two classes, five types and 16 subtypes. The relative stability of the classification suggests that the most prevalent variants of CRISPR?Cas systems are already known. However, the existence of rare, currently unclassifiable variants implies that additional types and subtypes remain to be characterized. Twit Text FOAVip An updated evolutionary classification of CRISPR Cas systems ????Nat Rev Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=26411297 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26411297 #FOAvip English Wikipedia <ref>{{Cite pmid|26411297}}</ref> An updated evolutionary classification of CRISPR?Cas systems #MMPMID26411297 Makarova KS; Wolf YI; Alkhnbashi OS; Costa F; Shah SA; Saunders SJ; Barrangou R; Brouns SJJ; Charpentier E; Haft DH; Horvath P; Moineau S; Mojica FJM; Terns RM; Terns MP; White MF; Yakunin AF; Garrett RA; van der Oost J; Backofen R; Koonin EV Nat Rev Microbiol 2015[Nov]; 13 (11): 722-36 PMID26411297show ga The evolution of CRISPR?cas loci, which encode adaptive immune systems in archaea and bacteria, involves rapid changes, in particular numerous rearrangements of the locus architecture and horizontal transfer of complete loci or individual modules. These dynamics complicate straightforward phylogenetic classification, but here we present an approach combining the analysis of signature protein families and features of the architecture of cas loci that unambiguously partitions most CRISPR?cas loci into distinct classes, types and subtypes. The new classification retains the overall structure of the previous version but is expanded to now encompass two classes, five types and 16 subtypes. The relative stability of the classification suggests that the most prevalent variants of CRISPR?Cas systems are already known. However, the existence of rare, currently unclassifiable variants implies that additional types and subtypes remain to be characterized. äAn updated evolutionary classification of CRISPR?Cas systems (epmc).pdf DeepDyve Pubget Overpricing