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10.1172/JCI78084 http://scihub22266oqcxt.onion/10.1172/JCI78084 C4497746!4497746!25938780     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25938780.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Clin+Invest 2015 ; 125 (6): 2194-202 Nephropedia Template TP {{tp|p=25938780|t=2015. Autoantibodies in systemic autoimmune diseases: specificity and pathogenicity |pdf=|usr=}}{{25938780}} gab.com Text Autoantibodies in systemic autoimmune diseases: specificity and pathogenicity JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=25938780 #FOAvip In this Review we focus on the initiation of autoantibody production and autoantibody pathogenicity, with a special emphasis on the targeted antigens. Release of intracellular antigens due to excessive cell death or to ineffective clearance of apoptotic debris, modification of self-antigens during inflammatory responses, and molecular mimicry contribute to the initiation of autoantibody production. We hypothesize that those autoreactive B cells that survive and produce pathogenic autoantibodies have specificity for self-antigens that are TLR ligands. Such B cells experience both B cell receptor (BCR) activation and TLR engagement, leading to an escape from tolerance. Moreover, the autoantibodies they produce form immune complexes that can activate myeloid cells and thereby establish the proinflammatory milieu that further negates tolerance mechanisms of both B and T cells. Twit Text FOAVip Autoantibodies in systemic autoimmune diseases: specificity and pathogenicity ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=25938780 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25938780 #FOAvip English Wikipedia <ref>{{Cite pmid|25938780}}</ref> Autoantibodies in systemic autoimmune diseases: specificity and pathogenicity #MMPMID25938780 Suurmond J; Diamond B J Clin Invest 2015[Jun]; 125 (6): 2194-202 PMID25938780show ga In this Review we focus on the initiation of autoantibody production and autoantibody pathogenicity, with a special emphasis on the targeted antigens. Release of intracellular antigens due to excessive cell death or to ineffective clearance of apoptotic debris, modification of self-antigens during inflammatory responses, and molecular mimicry contribute to the initiation of autoantibody production. We hypothesize that those autoreactive B cells that survive and produce pathogenic autoantibodies have specificity for self-antigens that are TLR ligands. Such B cells experience both B cell receptor (BCR) activation and TLR engagement, leading to an escape from tolerance. Moreover, the autoantibodies they produce form immune complexes that can activate myeloid cells and thereby establish the proinflammatory milieu that further negates tolerance mechanisms of both B and T cells. äAutoantibodies in systemic autoimmune diseases: specificity and pathog(epmc).pdf DeepDyve Pubget Overpricing