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10.1016/j.ajpath.2014.07.006 http://scihub22266oqcxt.onion/10.1016/j.ajpath.2014.07.006 C4215033!4215033!25194661     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25194661.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Pathol 2014 ; 184 (11): 3130-41 Nephropedia Template TP {{tp|p=25194661|t=2014. B2 Cells Suppress Experimental Abdominal Aortic Aneurysms |pdf=|usr=}}{{25194661}} gab.com Text B2 Cells Suppress Experimental Abdominal Aortic Aneurysms JO: Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=25194661 #FOAvip Recent reports of rupture in patients with abdominal aortic aneurysm (AAA) receiving B-cell depletion therapy highlight the importance of understanding the role of B cells (B1 and B2 subsets) in the development of AAA. We hypothesized that B2 cells aggravate experimental aneurysm formation. The IHC staining revealed infiltration of B cells in the aorta of wild-type (C57BL/6) mice at day 7 after elastase perfusion and persisted through day 21. Quantification of immune cell types using flow cytometry at day 14 showed significantly greater infiltration of mononuclear cells, including B cells (B2: 93% of total B cells) and T cells in elastase-perfused aortas compared with saline-perfused or normal aortas. muMT (mature B-cell deficient) mice were prone to AAA formation similar to wild-type mice in two different experimental AAA models. Contradicting our hypothesis, adoptive transfer of B2 cells suppressed AAA formation (102.0% � 7.3% versus 75.2% � 5.5%; P�<�0.05) with concomitant increase in the splenic regulatory T cell (0.24% � 0.03% versus 0.92% � 0.23%; P�<�0.05) and decrease in aortic infiltration of mononuclear cells. Our data suggest that B2 cells constitute the largest population of B cells in experimental AAA. Furthermore, B2 cells, in the absence of other B-cell subsets, increase splenic regulatory T-cell population and suppress AAA formation. Twit Text FOAVip B2 Cells Suppress Experimental Abdominal Aortic Aneurysms ????Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=25194661 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25194661 #FOAvip English Wikipedia <ref>{{Cite pmid|25194661}}</ref> B2 Cells Suppress Experimental Abdominal Aortic Aneurysms #MMPMID25194661 Meher AK; Johnston WF; Lu G; Pope NH; Bhamidipati CM; Harmon DB; Su G; Zhao Y; McNamara CA; Upchurch GR; Ailawadi G Am J Pathol 2014[Nov]; 184 (11): 3130-41 PMID25194661show ga Recent reports of rupture in patients with abdominal aortic aneurysm (AAA) receiving B-cell depletion therapy highlight the importance of understanding the role of B cells (B1 and B2 subsets) in the development of AAA. We hypothesized that B2 cells aggravate experimental aneurysm formation. The IHC staining revealed infiltration of B cells in the aorta of wild-type (C57BL/6) mice at day 7 after elastase perfusion and persisted through day 21. Quantification of immune cell types using flow cytometry at day 14 showed significantly greater infiltration of mononuclear cells, including B cells (B2: 93% of total B cells) and T cells in elastase-perfused aortas compared with saline-perfused or normal aortas. muMT (mature B-cell deficient) mice were prone to AAA formation similar to wild-type mice in two different experimental AAA models. Contradicting our hypothesis, adoptive transfer of B2 cells suppressed AAA formation (102.0% � 7.3% versus 75.2% � 5.5%; P�<�0.05) with concomitant increase in the splenic regulatory T cell (0.24% � 0.03% versus 0.92% � 0.23%; P�<�0.05) and decrease in aortic infiltration of mononuclear cells. Our data suggest that B2 cells constitute the largest population of B cells in experimental AAA. Furthermore, B2 cells, in the absence of other B-cell subsets, increase splenic regulatory T-cell population and suppress AAA formation. �B2 Cells Suppress Experimental Abdominal Aortic Aneurysms (epmc).pdf DeepDyve Pubget Overpricing