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10.18632/oncotarget.9917 http://scihub22266oqcxt.onion/10.18632/oncotarget.9917 C5593656!5593656!28924457     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28924457.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (34): 57451-9 Nephropedia Template TP {{tp|p=28924457|t=2017. BACH2 promotes indolent clinical presentation in Waldenström macroglobulinemia |pdf=|usr=}}{{28924457}} gab.com Text BACH2 promotes indolent clinical presentation in Waldenström macroglobulinemia JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28924457 #FOAvip Approximately 30% of the patients who fulfil the criteria of Waldenström's macroglobulinemia (WM) are diagnosed while asymptomatic (indolent), and will not require immediate therapy. Conversely, patients with a disease-related event will be considered for therapy. The physiopathology of these 2 groups remains unclear, and the mechanisms of progression from indolent to symptomatic WM have yet to be fully understood. Seventeen patients diagnosed with WM were included in this study, 8 asymptomatic WM (A-WM) and 9 symptomatic WM (S-WM). A differential analysis was performed on a first series of 11 patients and identified 48 genes whose expression separated samples from A- to S-WM. This gene signature was then confirmed on a second independent validation set of 6 WM. Within this expression profile, BACH2, a B-cell transcription factor known to be a tumor suppressor gene, was found to be over-expressed in A-MW relatively to S-MW. We specifically over-expressed BACH2 in a WM-related cell line and observed a significant reduction of the clonogenic activity. To the best of our knowledge, we report for the first time a specific gene expression signature that differentiates A-WM and S-WM. Within this expression profile, BACH2 was identified as a candidate gene that may help to understand better the behavior of tumor cells in indolent WM. Twit Text FOAVip BACH2 promotes indolent clinical presentation in Waldenström macroglobulinemia ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28924457 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28924457 #FOAvip English Wikipedia <ref>{{Cite pmid|28924457}}</ref> BACH2 promotes indolent clinical presentation in Waldenström macroglobulinemia #MMPMID28924457 Herbaux C; Bertrand E; Marot G; Roumier C; Poret N; Soenen V; Nibourel O; Roche-Lestienne C; Broucqsault N; Galiègue-Zouitina S; Boyle EM; Fouquet G; Renneville A; Tricot S; Morschhauser F; Preudhomme C; Quesnel B; Poulain S; Leleu X Oncotarget 2017[Aug]; 8 (34): 57451-9 PMID28924457show ga Approximately 30% of the patients who fulfil the criteria of Waldenström's macroglobulinemia (WM) are diagnosed while asymptomatic (indolent), and will not require immediate therapy. Conversely, patients with a disease-related event will be considered for therapy. The physiopathology of these 2 groups remains unclear, and the mechanisms of progression from indolent to symptomatic WM have yet to be fully understood. Seventeen patients diagnosed with WM were included in this study, 8 asymptomatic WM (A-WM) and 9 symptomatic WM (S-WM). A differential analysis was performed on a first series of 11 patients and identified 48 genes whose expression separated samples from A- to S-WM. This gene signature was then confirmed on a second independent validation set of 6 WM. Within this expression profile, BACH2, a B-cell transcription factor known to be a tumor suppressor gene, was found to be over-expressed in A-MW relatively to S-MW. We specifically over-expressed BACH2 in a WM-related cell line and observed a significant reduction of the clonogenic activity. To the best of our knowledge, we report for the first time a specific gene expression signature that differentiates A-WM and S-WM. Within this expression profile, BACH2 was identified as a candidate gene that may help to understand better the behavior of tumor cells in indolent WM. äBACH2 promotes indolent clinical presentation in Waldenström macroglob(epmc).pdf DeepDyve Pubget Overpricing