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10.1038/s41598-017-04316-1

http://scihub22266oqcxt.onion/10.1038/s41598-017-04316-1
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suck abstract from ncbi


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pmid28642488      Sci+Rep 2017 ; 7 (�): �
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  • Biomimetic Molecular Signaling using DNA Walkers on Microparticles #MMPMID28642488
  • Damase TR; Spencer A; Samuel B; Allen PB
  • Sci Rep 2017[]; 7 (�): � PMID28642488show ga
  • We report the release of catalytic DNA walkers from hydrogel microparticles and the detection of those walkers by substrate-coated microparticles. This might be considered a synthetic biology analog of molecular signal release and reception. One type of particles was coated with components of a DNA one-step strand displacement (OSD) reaction to release the walker. A second type of particle was coated with substrate (or ?track?) for the molecular walker. We distinguish these particle types using fluorescence barcoding: we synthesized and distinguished multiple particle types with multicolor fluorescence microscopy and automated image analysis software. This represents a step toward amplified, multiplex, and microscopically localized detection based on DNA nanotechnology.



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