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CAR T-cell Therapy for Pancreatic Cancer #MMPMID28346697
D\elm C; Tano ZE; Varghese AM; Adusumilli PS
J Surg Oncol 2017[Jul]; 116 (1): 63-74 PMID28346697show ga
Chimeric antigen receptor (CAR) T-cell therapy utilizes genetic engineering to redirect a patient?s own T cells to target cancer cells. The remarkable results in hematological malignancies prompted investigating this approach in solid tumors such as pancreatic cancer. The complex tumor microenvironment, stromal hindrance in limiting immune response, and expression of checkpoint blockade on T cells poses hurdles. Herein, we summarize the opportunities, challenges, and state of knowledge in targeting pancreatic cancer with CAR T-cell therapy.