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10.1038/s41467-017-00607-3 http://scihub22266oqcxt.onion/10.1038/s41467-017-00607-3 C5599616!5599616!28912502     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28912502&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28912502.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28912502|t=2017. Caloric restriction delays age-related methylation drift |pdf=|usr=}}{{28912502}} gab.com Text Caloric restriction delays age-related methylation drift JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28912502 #FOAvip In mammals, caloric restriction consistently results in extended lifespan. Epigenetic information encoded by DNA methylation is tightly regulated, but shows a striking drift associated with age that includes both gains and losses of DNA methylation at various sites. Here, we report that epigenetic drift is conserved across species and the rate of drift correlates with lifespan when comparing mice, rhesus monkeys, and humans. Twenty-two to 30-year-old rhesus monkeys exposed to 30% caloric restriction since 7?14 years of age showed attenuation of age-related methylation drift compared to ad libitum-fed controls such that their blood methylation age appeared 7 years younger than their chronologic age. Even more pronounced effects were seen in 2.7?3.2-year-old mice exposed to 40% caloric restriction starting at 0.3 years of age. The effects of caloric restriction on DNA methylation were detectable across different tissues and correlated with gene expression. We propose that epigenetic drift is a determinant of lifespan in mammals. Twit Text FOAVip Caloric restriction delays age-related methylation drift ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28912502 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28912502 #FOAvip English Wikipedia <ref>{{Cite pmid|28912502}}</ref> Caloric restriction delays age-related methylation drift #MMPMID28912502 Maegawa S; Lu Y; Tahara T; Lee JT; Madzo J; Liang S; Jelinek J; Colman RJ; Issa JPJ Nat Commun 2017[]; 8 (ä): ä PMID28912502show ga In mammals, caloric restriction consistently results in extended lifespan. Epigenetic information encoded by DNA methylation is tightly regulated, but shows a striking drift associated with age that includes both gains and losses of DNA methylation at various sites. Here, we report that epigenetic drift is conserved across species and the rate of drift correlates with lifespan when comparing mice, rhesus monkeys, and humans. Twenty-two to 30-year-old rhesus monkeys exposed to 30% caloric restriction since 7?14 years of age showed attenuation of age-related methylation drift compared to ad libitum-fed controls such that their blood methylation age appeared 7 years younger than their chronologic age. Even more pronounced effects were seen in 2.7?3.2-year-old mice exposed to 40% caloric restriction starting at 0.3 years of age. The effects of caloric restriction on DNA methylation were detectable across different tissues and correlated with gene expression. We propose that epigenetic drift is a determinant of lifespan in mammals. äCaloric restriction delays age-related methylation drift (epmc).pdf DeepDyve Pubget Overpricing