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10.1038/nn.4171 http://scihub22266oqcxt.onion/10.1038/nn.4171 C4700510!4700510!26571460     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26571460.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Neurosci 2015 ; 18 (12): 1832-44 Nephropedia Template TP {{tp|p=26571460|t=2015. Canonical Genetic Signatures of the Adult Human Brain |pdf=|usr=}}{{26571460}} gab.com Text Canonical Genetic Signatures of the Adult Human Brain JO: Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=26571460 #FOAvip The structure and function of the human brain are highly stereotyped, implying a conserved molecular program responsible for its development, cellular structure, and function. We applied a correlation-based metric of ?differential stability? (DS) to assess reproducibility of gene expression patterning across 132 structures in six individual brains, revealing meso-scale genetic organization. The highest DS genes are highly biologically relevant, with enrichment for brain-related biological annotations, disease associations, drug targets, and literature citations. Using high DS genes we identified 32 anatomically diverse and reproducible gene expression signatures, which represent distinct cell types, intracellular components, and/or associations with neurodevelopmental and neurodegenerative disorders. Genes in neuron-associated compared to non-neuronal networks showed higher preservation between human and mouse; however, many diversely-patterned genes displayed dramatic shifts in regulation between species. Finally, highly consistent transcriptional architecture in neocortex is correlated with resting state functional connectivity, suggesting a link between conserved gene expression and functionally relevant circuitry. Twit Text FOAVip Canonical Genetic Signatures of the Adult Human Brain ????Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=26571460 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26571460 #FOAvip English Wikipedia <ref>{{Cite pmid|26571460}}</ref> Canonical Genetic Signatures of the Adult Human Brain #MMPMID26571460 Hawrylycz M; Miller JA; Menon V; Feng D; Dolbeare T; Guillozet-Bongaarts AL; Jegga AG; Aronow BJ; Lee CK; Bernard A; Glasser MF; Dierker DL; Menche J; Szafer A; Collman F; Grange P; Berman KA; Mihalas S; Yao Z; Stewart L; Barabási AL; Schulkin J; Phillips J; Ng L; Dang C; Haynor DR; Jones A; Van Essen DC; Koch C; Lein E Nat Neurosci 2015[Dec]; 18 (12): 1832-44 PMID26571460show ga The structure and function of the human brain are highly stereotyped, implying a conserved molecular program responsible for its development, cellular structure, and function. We applied a correlation-based metric of ?differential stability? (DS) to assess reproducibility of gene expression patterning across 132 structures in six individual brains, revealing meso-scale genetic organization. The highest DS genes are highly biologically relevant, with enrichment for brain-related biological annotations, disease associations, drug targets, and literature citations. Using high DS genes we identified 32 anatomically diverse and reproducible gene expression signatures, which represent distinct cell types, intracellular components, and/or associations with neurodevelopmental and neurodegenerative disorders. Genes in neuron-associated compared to non-neuronal networks showed higher preservation between human and mouse; however, many diversely-patterned genes displayed dramatic shifts in regulation between species. Finally, highly consistent transcriptional architecture in neocortex is correlated with resting state functional connectivity, suggesting a link between conserved gene expression and functionally relevant circuitry. äCanonical Genetic Signatures of the Adult Human Brain (epmc).pdf DeepDyve Pubget Overpricing