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10.1016/j.neuroscience.2017.05.013 http://scihub22266oqcxt.onion/10.1016/j.neuroscience.2017.05.013 28526576!ä!28526576 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28526576&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28526576.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Neuroscience 2017 ; 356 (ä): 176-181 Nephropedia Template TP {{tp|p=28526576|t=2017. Carvacrol promotes neuroprotection in the mouse hemiparkinsonian model |pdf=|usr=}}{{28526576}} gab.com Text Carvacrol promotes neuroprotection in the mouse hemiparkinsonian model JO: Neuroscience http://www.kidney.de/pget.php?&tw=1&pmid=28526576 #FOAvip Carvacrol is a monoterpene that has been linked to neuroprotection in several animal models of neurodegeneration, including ischemia, epilepsy and traumatic neuronal injury. In this study, we investigated the effects of carvacrol (i.p.) upon the neurodegeneration induced by 6-hydroxy-dopamine unilateral intrastriatal injections in mice. We have also used the cylinder test to assess the behavioral effects of carvacrol in that model of Parkinson's disease, and immunoblots to evaluate the levels of caspase-3 and TRPM7, one of major targets of carvacrol. Behavioral testing revealed that carvacrol largely reduced the asymmetrical use of the forelimbs induced by unilateral 6-hydroxy-dopamine. Carvacrol dramatically reduced the loss of tyrosine hydroxylase immunostaining both in the substantia nigra and in the striatum that are typical of the model. Immunoblots for tyrosine hydroxylase confirmed this effect. Caspase-3 levels were very high after toxin injections, but carvacrol appeared to reduce them to control levels. Finally, TRPM7, observed by immunoblots, increased after 6-hydroxy-dopamine, suggesting the involvement of this cation channel in the ensuing neurodegenerative process. The present data suggest that carvacrol promotes a marked neuroprotection in the 6-hydroxy-dopamine model of Parkinson's disease, possibly by its non-specific blocking effect upon TRPM7 channels. Twit Text FOAVip Carvacrol promotes neuroprotection in the mouse hemiparkinsonian model ????Neuroscience http://www.kidney.de/pget.php?&tw=1&pmid=28526576 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28526576 #FOAvip English Wikipedia <ref>{{Cite pmid|28526576}}</ref> Carvacrol promotes neuroprotection in the mouse hemiparkinsonian model #MMPMID28526576 Dati LM; Ulrich H; Real CC; Feng ZP; Sun HS; Britto LR Neuroscience 2017[Jul]; 356 (ä): 176-181 PMID28526576show ga Carvacrol is a monoterpene that has been linked to neuroprotection in several animal models of neurodegeneration, including ischemia, epilepsy and traumatic neuronal injury. In this study, we investigated the effects of carvacrol (i.p.) upon the neurodegeneration induced by 6-hydroxy-dopamine unilateral intrastriatal injections in mice. We have also used the cylinder test to assess the behavioral effects of carvacrol in that model of Parkinson's disease, and immunoblots to evaluate the levels of caspase-3 and TRPM7, one of major targets of carvacrol. Behavioral testing revealed that carvacrol largely reduced the asymmetrical use of the forelimbs induced by unilateral 6-hydroxy-dopamine. Carvacrol dramatically reduced the loss of tyrosine hydroxylase immunostaining both in the substantia nigra and in the striatum that are typical of the model. Immunoblots for tyrosine hydroxylase confirmed this effect. Caspase-3 levels were very high after toxin injections, but carvacrol appeared to reduce them to control levels. Finally, TRPM7, observed by immunoblots, increased after 6-hydroxy-dopamine, suggesting the involvement of this cation channel in the ensuing neurodegenerative process. The present data suggest that carvacrol promotes a marked neuroprotection in the 6-hydroxy-dopamine model of Parkinson's disease, possibly by its non-specific blocking effect upon TRPM7 channels. |Animals[MESH] |Cymenes[MESH] |Disease Models, Animal[MESH] |Male[MESH] |Mice, Inbred C57BL[MESH] |Monoterpenes/*pharmacology[MESH] |Neurons/*drug effects/metabolism[MESH] |Neuroprotection/*drug effects[MESH] |Neuroprotective Agents/*pharmacology[MESH] |Parkinson Disease/*drug therapy[MESH]Carvacrol promotes neuroprotection in the mouse hemiparkinsonian model(epmc).pdf DeepDyve Pubget Overpricing