
| 10.1002/lary.24956
http://scihub22266oqcxt.onion/10.1002/lary.24956
 C4562418!4562418!25290987
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Laryngoscope 2015 ; 125 (5): 1137-43 Nephropedia Template TP
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Causes and Consequences of Adult Laryngotracheal Stenosis #MMPMID25290987Gelbard A; Francis DO; Sandulache VC; Simmons JC; Donovan DT; Ongkasuwan JLaryngoscope 2015[May]; 125 (5): 1137-43 PMID25290987show ga
Objective: Laryngotracheal stenosis is largely considered a structural entity, defined on anatomic terms (i.e. percent stenosis, distance from vocal folds, overall length). This has significant implications for identifying at-risk populations, devising systems-based preventive strategies, and promoting patient-centered treatment. The present study was undertaken to test the hypothesis that LTS is heterogeneous in regard to etiology, natural history, and clinical outcome. Study Design: Retrospective cohort study of consecutive adult tracheal stenosis patients from 1998?2013. Methods: Subjects diagnosed with laryngotracheal stenosis (ICD-9: 478.74, 519.19) between January 1, 1998 and January 1, 2013 were identified. Patient characteristics (age, gender, race, follow-up duration), and comorbidities were extracted. Records were reviewed for etiology of stenosis, treatment approach, and surgical dates. Stenosis morphology was derived from intraoperative measurements. The presence of tracheostomy at last follow-up was recorded. Results: 150 patients met inclusion criteria. 54.7% had an iatrogenic etiology followed by idiopathic (18.5%), autoimmune (18.5%), and traumatic (8%). Tracheostomy dependence differed based on etiology (p<0.001). Significantly more patients with iatrogenic (66%) and autoimmune (54%) etiologies remained tracheostomy dependent compared to traumatic (33%) or idiopathic (0%) groups. On multivariate regression analysis, each additional point on Charlson Comorbidity Index was associated with a 67% increased odds of tracheostomy dependence (OR 1.67, 95% CI 1.04 ? 2.69; p=0.04). Conclusions: Laryngotracheal stenosis is not a homogeneous clinical entity. It has multiple distinct etiologies that demonstrate disparate rates of long-term tracheostomy dependence. Understanding the mechanism of injury and contribution of comorbid illnesses is critical to systems-based preventive strategies and patient-centered treatment.�
  
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