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Changes in kidney function among Nicaraguan sugarcane workers #MMPMID25631575
Int J Occup Environ Health 2015[Mar]; 21 (3): 241-50 PMID25631575show ga
Background:: There is an epidemic of chronic kidney disease (CKD) of unknown etiology in Central American workers. Objectives:: To investigate changes and job-specific differences in kidney function over a 6-month sugarcane harvest season, explore the potential role of hydration, and measure proteinuria. Methods:: We recruited 284 Nicaraguan sugarcane workers performing seven distinct tasks. We measured urine albumin and serum creatinine and estimated glomerular filtration rate (eGFR). Results:: eGFR varied by job and decreased during the harvest in seed cutters (?8.6 ml/min/1.73 m2), irrigators (?7.4 ml/min/1.73 m2), and cane cutters (?5.0 ml/min/1.73 m2), as compared to factory workers. The number of years employed at the company was negatively associated with eGFR. Fewer than 5% of workers had albumin-to-creatinine ratio (ACR) >30 mg/g. Conclusions:: The decline in kidney function during the harvest and the differences by job category and employment duration provide evidence that one or more risk factors of CKD are occupational.