Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1007/s13277-015-4337-7 http://scihub22266oqcxt.onion/10.1007/s13277-015-4337-7 C4844647!4844647!26537586     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26537586.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Tumour+Biol 2016 ; 37 (4): 5025-30 Nephropedia Template TP {{tp|p=26537586|t=2016. Chemotherapy promotes tumour cell hybridization in vivo |pdf=|usr=}}{{26537586}} gab.com Text Chemotherapy promotes tumour cell hybridization in vivo JO: Tumour Biol http://www.kidney.de/pget.php?&tw=1&pmid=26537586 #FOAvip Spontaneous cell-cell fusion has been recognized to be an important mechanism for tissue and organ development and repair. In cancer, cell fusion is critically involved in tumourigenesis, metastasis and drug resistance, as illustrated by in vitro experiments. However, there has been no direct detection of tumour cell fusion or hybridization in an in vivo tumour environment, and the features of hybridized cells under selective pressures, such as chemotherapy, are unknown. Here, we expressed two fluorescent marker proteins in the human breast cancer cell line SKBR3 to detect tumour cell hybridization in vivo and performed a xenograft chemotherapy experiment in mice to evaluate the chemotherapeutic response of the hybrids. The mice treated by epirubicin showed that chemotherapy promoted tumour cell hybridization in vivo, which elicited the production of more hybrids in the outer section of the tumour. These results provide the first in vivo evidence of tumour cell fusion and indicate that chemotherapy may contribute to a poor prognosis by enriching for fused cells, which are more malignant. It is therefore necessary to reassess chemotherapy strategies.Electronic supplementary material: The online version of this article (doi:10.1007/s13277-015-4337-7) contains supplementary material, which is available to authorized users. Twit Text FOAVip Chemotherapy promotes tumour cell hybridization in vivo ????Tumour Biol http://www.kidney.de/pget.php?&tw=1&pmid=26537586 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26537586 #FOAvip English Wikipedia <ref>{{Cite pmid|26537586}}</ref> Chemotherapy promotes tumour cell hybridization in vivo #MMPMID26537586 Yan B; Wang J; Liu L Tumour Biol 2016[Apr]; 37 (4): 5025-30 PMID26537586show ga Spontaneous cell-cell fusion has been recognized to be an important mechanism for tissue and organ development and repair. In cancer, cell fusion is critically involved in tumourigenesis, metastasis and drug resistance, as illustrated by in vitro experiments. However, there has been no direct detection of tumour cell fusion or hybridization in an in vivo tumour environment, and the features of hybridized cells under selective pressures, such as chemotherapy, are unknown. Here, we expressed two fluorescent marker proteins in the human breast cancer cell line SKBR3 to detect tumour cell hybridization in vivo and performed a xenograft chemotherapy experiment in mice to evaluate the chemotherapeutic response of the hybrids. The mice treated by epirubicin showed that chemotherapy promoted tumour cell hybridization in vivo, which elicited the production of more hybrids in the outer section of the tumour. These results provide the first in vivo evidence of tumour cell fusion and indicate that chemotherapy may contribute to a poor prognosis by enriching for fused cells, which are more malignant. It is therefore necessary to reassess chemotherapy strategies.Electronic supplementary material: The online version of this article (doi:10.1007/s13277-015-4337-7) contains supplementary material, which is available to authorized users. äChemotherapy promotes tumour cell hybridization in vivo (epmc).pdf DeepDyve Pubget Overpricing