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10.1615/CritRevEukaryotGeneExpr.2016015724 http://scihub22266oqcxt.onion/10.1615/CritRevEukaryotGeneExpr.2016015724 C5470591!5470591!27480773     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27480773&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27480773.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Crit+Rev+Eukaryot+Gene+Expr 2016 ; 26 (2): 97-113 Nephropedia Template TP {{tp|p=27480773|t=2016. Clinical Genomics: Challenges and Opportunities |pdf=|usr=}}{{27480773}} gab.com Text Clinical Genomics: Challenges and Opportunities JO: Crit Rev Eukaryot Gene Expr http://www.kidney.de/pget.php?&tw=1&pmid=27480773 #FOAvip Next-generation sequencing (NGS) approaches are highly applicable to clinical studies. We review recent advances in sequencing technologies, as well as their benefits and tradeoffs, to provide an overview of clinical genomics from study design to computational analysis. Sequencing technologies enable genomic, transcriptomic, and epigenomic evaluations. Studies that use a combination of whole genome, exome, mRNA, and bisulfite sequencing are now feasible due to decreasing sequencing costs. Single-molecule sequencing increases read length, with the MinION? nanopore sequencer, which offers a uniquely portable option at a lower cost. Many of the published comparisons we review here address the challenges associated with different sequencing methods. Overall, NGS techniques, coupled with continually improving analysis algorithms, are useful for clinical studies in many realms, including cancer, chronic illness, and neurobiology. We, and others in the field, anticipate the clinical use of NGS approaches will continue to grow, especially as we shift into an era of precision medicine. Twit Text FOAVip Clinical Genomics: Challenges and Opportunities ????Crit Rev Eukaryot Gene Expr http://www.kidney.de/pget.php?&tw=1&pmid=27480773 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27480773 #FOAvip English Wikipedia <ref>{{Cite pmid|27480773}}</ref> Clinical Genomics: Challenges and Opportunities #MMPMID27480773 Vijay P; McIntyre AB; Mason CE; Greenfield JP; Li S Crit Rev Eukaryot Gene Expr 2016[]; 26 (2): 97-113 PMID27480773show ga Next-generation sequencing (NGS) approaches are highly applicable to clinical studies. We review recent advances in sequencing technologies, as well as their benefits and tradeoffs, to provide an overview of clinical genomics from study design to computational analysis. Sequencing technologies enable genomic, transcriptomic, and epigenomic evaluations. Studies that use a combination of whole genome, exome, mRNA, and bisulfite sequencing are now feasible due to decreasing sequencing costs. Single-molecule sequencing increases read length, with the MinION? nanopore sequencer, which offers a uniquely portable option at a lower cost. Many of the published comparisons we review here address the challenges associated with different sequencing methods. Overall, NGS techniques, coupled with continually improving analysis algorithms, are useful for clinical studies in many realms, including cancer, chronic illness, and neurobiology. We, and others in the field, anticipate the clinical use of NGS approaches will continue to grow, especially as we shift into an era of precision medicine. äClinical Genomics: Challenges and Opportunities (epmc).pdf DeepDyve Pubget Overpricing