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10.4161/21623988.2014.970459 http://scihub22266oqcxt.onion/10.4161/21623988.2014.970459 C4580081!4580081!26413421     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26413421.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       JAKSTAT 2014 ; 3 (3): ä Nephropedia Template TP {{tp|p=26413421|t=2014. Contribution of chaperones to STAT pathway signaling |pdf=|usr=}}{{26413421}} gab.com Text Contribution of chaperones to STAT pathway signaling JO: JAKSTAT http://www.kidney.de/pget.php?&tw=1&pmid=26413421 #FOAvip Aberrant STAT signaling is associated with the development and progression of many cancers and immune related diseases. Recent findings demonstrate that proteostasis modulators under clinical investigation for cancer therapy have a significant impact on STAT signaling, which may be critical for mediating their anti-cancer effects. Chaperones are critical for protein folding, stability and function and, thus, play an essential role in the maintenance of proteostasis. In this review we discuss the role of chaperones in STAT and tyrosine kinase (TK) protein folding, modulation of STAT and TK activity, and degradation of TKs. We highlight the important role of chaperones in STAT signaling, and how this knowledge has provided a framework for the development of new therapeutic avenues of targeting STAT signaling related pathologies. Twit Text FOAVip Contribution of chaperones to STAT pathway signaling ????JAKSTAT http://www.kidney.de/pget.php?&tw=1&pmid=26413421 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26413421 #FOAvip English Wikipedia <ref>{{Cite pmid|26413421}}</ref> Contribution of chaperones to STAT pathway signaling #MMPMID26413421 Bocchini CE; Kasembeli MM; Roh SH; Tweardy DJ JAKSTAT 2014[]; 3 (3): ä PMID26413421show ga Aberrant STAT signaling is associated with the development and progression of many cancers and immune related diseases. Recent findings demonstrate that proteostasis modulators under clinical investigation for cancer therapy have a significant impact on STAT signaling, which may be critical for mediating their anti-cancer effects. Chaperones are critical for protein folding, stability and function and, thus, play an essential role in the maintenance of proteostasis. In this review we discuss the role of chaperones in STAT and tyrosine kinase (TK) protein folding, modulation of STAT and TK activity, and degradation of TKs. We highlight the important role of chaperones in STAT signaling, and how this knowledge has provided a framework for the development of new therapeutic avenues of targeting STAT signaling related pathologies. äContribution of chaperones to STAT pathway signaling (epmc).pdf DeepDyve Pubget Overpricing