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10.1172/JCI84144 http://scihub22266oqcxt.onion/10.1172/JCI84144 C4922699!4922699!27367183     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27367183.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Clin+Invest ä ; 126 (7): 2394-403 Nephropedia Template TP {{tp|p=27367183|t=ä. Current concepts of severe asthma |pdf=|usr=}}{{27367183}} gab.com Text Current concepts of severe asthma JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=27367183 #FOAvip The term asthma encompasses a disease spectrum with mild to very severe disease phenotypes whose traditional common characteristic is reversible airflow limitation. Unlike milder disease, severe asthma is poorly controlled by the current standard of care. Ongoing studies using advanced molecular and immunological tools along with improved clinical classification show that severe asthma does not identify a specific patient phenotype, but rather includes patients with constant medical needs, whose pathobiologic and clinical characteristics vary widely. Accordingly, in recent clinical trials, therapies guided by specific patient characteristics have had better outcomes than previous therapies directed to any subject with a diagnosis of severe asthma. However, there are still significant gaps in our understanding of the full scope of this disease that hinder the development of effective treatments for all severe asthmatics. In this Review, we discuss our current state of knowledge regarding severe asthma, highlighting different molecular and immunological pathways that can be targeted for future therapeutic development. Twit Text FOAVip Current concepts of severe asthma ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=27367183 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27367183 #FOAvip English Wikipedia <ref>{{Cite pmid|27367183}}</ref> Current concepts of severe asthma #MMPMID27367183 Ray A; Raundhal M; Oriss TB; Ray P; Wenzel SE J Clin Invest ä[]; 126 (7): 2394-403 PMID27367183show ga The term asthma encompasses a disease spectrum with mild to very severe disease phenotypes whose traditional common characteristic is reversible airflow limitation. Unlike milder disease, severe asthma is poorly controlled by the current standard of care. Ongoing studies using advanced molecular and immunological tools along with improved clinical classification show that severe asthma does not identify a specific patient phenotype, but rather includes patients with constant medical needs, whose pathobiologic and clinical characteristics vary widely. Accordingly, in recent clinical trials, therapies guided by specific patient characteristics have had better outcomes than previous therapies directed to any subject with a diagnosis of severe asthma. However, there are still significant gaps in our understanding of the full scope of this disease that hinder the development of effective treatments for all severe asthmatics. In this Review, we discuss our current state of knowledge regarding severe asthma, highlighting different molecular and immunological pathways that can be targeted for future therapeutic development. äCurrent concepts of severe asthma (epmc).pdf DeepDyve Pubget Overpricing