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Current Detection Technologies of Circulating Tumor Cells #MMPMID28393954
Shen Z; Wu A; Chen X
Chem Soc Rev 2017[Apr]; 46 (8): 2038-56 PMID28393954show ga
Circulating tumor cells (CTCs) are cancer cells that circulate in the blood stream after being naturally shed from original or metastatic tumors, and can lead to a new fatal metastasis. CTCs have become a hotspot research field during the last decade. Detection of CTCs, as a liquid biopsy of tumors, can be used for early diagnosis of cancers, earlier evaluation of cancer recurrence and chemotherapeutic efficacy, and choice of individual sensitive anti-cancer drugs. Therefore, CTC detection is a crucial tool to fight against cancer. Herein, we classify the currently reported CTC detection technologies, introduce some representative samples for each technology, conclude the advantages and limitations, and give a future prospective including challenges and opportunities of CTC detection.