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10.4049/jimmunol.1601226 http://scihub22266oqcxt.onion/10.4049/jimmunol.1601226 C5469413!5469413!28411186     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28411186.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol 2017 ; 198 (10): 4036-45 Nephropedia Template TP {{tp|p=28411186|t=2017. Direct antimicrobial activity of Interferon-? |pdf=|usr=}}{{28411186}} gab.com Text Direct antimicrobial activity of Interferon- JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28411186 #FOAvip Type I interferons are a cytokine family essential for antiviral defense. More recently, type I interferons have been shown to be important during bacterial infections. Here we show that, in addition to known cytokine functions, interferon-? (IFN-?) is also antimicrobial. Parts of the IFN-? molecular surface (especially helix 4) are cationic and amphipathic, both classic characteristics of antimicrobial peptides, and we have observed that IFN-? can directly kill Staphylococcus aureus. Further, a mutant S. aureus that is more sensitive to antimicrobial peptides was killed more efficiently by IFN-? than the wild-type S. aureus, and immunoblotting showed that IFN-? interacts with the bacterial cell surface. To determine whether specific parts of IFN-? are antimicrobial, we synthesized IFN-? helix 4 and found that it is sufficient to permeate model prokaryotic membranes using synchrotron x-ray diffraction and that it is sufficient to kill S. aureus. These results suggest that in addition to its well-known signaling activity, IFN-? may be directly antimicrobial and be part of a growing family of cytokines and chemokines, called kinocidins, that also have antimicrobial properties. Twit Text FOAVip Direct antimicrobial activity of Interferon- ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28411186 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28411186 #FOAvip English Wikipedia <ref>{{Cite pmid|28411186}}</ref> Direct antimicrobial activity of Interferon-? #MMPMID28411186 Kaplan A; Lee MW; Wolf AJ; Limon J; Becker CA; Ding M; Murali R; Lee EY; Liu GY; Wong GCL; Underhill DM J Immunol 2017[May]; 198 (10): 4036-45 PMID28411186show ga Type I interferons are a cytokine family essential for antiviral defense. More recently, type I interferons have been shown to be important during bacterial infections. Here we show that, in addition to known cytokine functions, interferon-? (IFN-?) is also antimicrobial. Parts of the IFN-? molecular surface (especially helix 4) are cationic and amphipathic, both classic characteristics of antimicrobial peptides, and we have observed that IFN-? can directly kill Staphylococcus aureus. Further, a mutant S. aureus that is more sensitive to antimicrobial peptides was killed more efficiently by IFN-? than the wild-type S. aureus, and immunoblotting showed that IFN-? interacts with the bacterial cell surface. To determine whether specific parts of IFN-? are antimicrobial, we synthesized IFN-? helix 4 and found that it is sufficient to permeate model prokaryotic membranes using synchrotron x-ray diffraction and that it is sufficient to kill S. aureus. These results suggest that in addition to its well-known signaling activity, IFN-? may be directly antimicrobial and be part of a growing family of cytokines and chemokines, called kinocidins, that also have antimicrobial properties. äDirect antimicrobial activity of Interferon-? (epmc).pdf DeepDyve Pubget Overpricing