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10.1021/acs.biomac.7b00068 http://scihub22266oqcxt.onion/10.1021/acs.biomac.7b00068 C5424079!5424079!28328191     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28328191&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28328191.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biomacromolecules 2017 ; 18 (5): 1449-59 Nephropedia Template TP {{tp|p=28328191|t=2017. Enhancing Tumor Penetration of Nanomedicines |pdf=|usr=}}{{28328191}} gab.com Text Enhancing Tumor Penetration of Nanomedicines JO: Biomacromolecules http://www.kidney.de/pget.php?&tw=1&pmid=28328191 #FOAvip Tumor-targeted nanomedicines have been extensively applied to alter the drawbacks and enhance the efficacy of chemotherapeutics. Despite the large number of preclinical nanomedicine studies showing initial success, their therapeutic benefit in the clinic has been rather modest, which is partially due to the inefficient tumor penetration caused by tumor microenvironment (high density of cells and extracellular matrix, increased interstitial fluid pressure). Furthermore, tumor penetration of nanomedicines is significantly influenced by physicochemical characteristics such as size, surface chemistry and shape. The effect of size on tumor penetration has been exploited to design nanomedicines with switchable size to tackle this challenge. Moreover, several pharmacological and physical approaches have been developed to enhance the tumor penetration of nanomedicines, by penetration-promoting ligands, intratumoral drug release, and modulating the tumor microenvironment and vasculature. Overall, these efforts have resulted in nanomedicines with better tumor penetration properties and with enhanced therapeutic efficacy. Future research should be directed to penetration-promoting strategies with broad applicability and with high translational potential. Twit Text FOAVip Enhancing Tumor Penetration of Nanomedicines ????Biomacromolecules http://www.kidney.de/pget.php?&tw=1&pmid=28328191 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28328191 #FOAvip English Wikipedia <ref>{{Cite pmid|28328191}}</ref> Enhancing Tumor Penetration of Nanomedicines #MMPMID28328191 Sun Q; Ojha T; Kiessling F; Lammers T; Shi Y Biomacromolecules 2017[May]; 18 (5): 1449-59 PMID28328191show ga Tumor-targeted nanomedicines have been extensively applied to alter the drawbacks and enhance the efficacy of chemotherapeutics. Despite the large number of preclinical nanomedicine studies showing initial success, their therapeutic benefit in the clinic has been rather modest, which is partially due to the inefficient tumor penetration caused by tumor microenvironment (high density of cells and extracellular matrix, increased interstitial fluid pressure). Furthermore, tumor penetration of nanomedicines is significantly influenced by physicochemical characteristics such as size, surface chemistry and shape. The effect of size on tumor penetration has been exploited to design nanomedicines with switchable size to tackle this challenge. Moreover, several pharmacological and physical approaches have been developed to enhance the tumor penetration of nanomedicines, by penetration-promoting ligands, intratumoral drug release, and modulating the tumor microenvironment and vasculature. Overall, these efforts have resulted in nanomedicines with better tumor penetration properties and with enhanced therapeutic efficacy. Future research should be directed to penetration-promoting strategies with broad applicability and with high translational potential. äEnhancing Tumor Penetration of Nanomedicines (epmc).pdf DeepDyve Pubget Overpricing