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10.3389/fimmu.2015.00405 http://scihub22266oqcxt.onion/10.3389/fimmu.2015.00405 C4566074!4566074!26441954     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26441954.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Immunol 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26441954|t=2015. Epigenetic Codes Programing Class Switch Recombination |pdf=|usr=}}{{26441954}} gab.com Text Epigenetic Codes Programing Class Switch Recombination JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26441954 #FOAvip Class switch recombination imparts B cells with a fitness-associated adaptive ­advantage during a humoral immune response by using a precision-tailored DNA excision and ligation process to swap the default constant region gene of the antibody with a new one that has unique effector functions. This secondary diversification of the antibody repertoire is a hallmark of the adaptability of B cells when confronted with environmental and pathogenic challenges. Given that the nucleotide sequence of genes during class switching remains unchanged (genetic constraints), it is logical and necessary therefore, to integrate the adaptability of B cells to an epigenetic state, which is dynamic and can be heritably modulated before, after, or even during an antibody-dependent immune response. Epigenetic regulation encompasses heritable changes that affect function (phenotype) without altering the sequence information embedded in a gene, and include histone, DNA and RNA modifications. Here, we review current literature on how B cells use an epigenetic code language as a means to ensure antibody plasticity in light of pathogenic insults. Twit Text FOAVip Epigenetic Codes Programing Class Switch Recombination ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26441954 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26441954 #FOAvip English Wikipedia <ref>{{Cite pmid|26441954}}</ref> Epigenetic Codes Programing Class Switch Recombination #MMPMID26441954 Vaidyanathan B; Chaudhuri J Front Immunol 2015[]; 6 (ä): ä PMID26441954show ga Class switch recombination imparts B cells with a fitness-associated adaptive ­advantage during a humoral immune response by using a precision-tailored DNA excision and ligation process to swap the default constant region gene of the antibody with a new one that has unique effector functions. This secondary diversification of the antibody repertoire is a hallmark of the adaptability of B cells when confronted with environmental and pathogenic challenges. Given that the nucleotide sequence of genes during class switching remains unchanged (genetic constraints), it is logical and necessary therefore, to integrate the adaptability of B cells to an epigenetic state, which is dynamic and can be heritably modulated before, after, or even during an antibody-dependent immune response. Epigenetic regulation encompasses heritable changes that affect function (phenotype) without altering the sequence information embedded in a gene, and include histone, DNA and RNA modifications. Here, we review current literature on how B cells use an epigenetic code language as a means to ensure antibody plasticity in light of pathogenic insults. äEpigenetic Codes Programing Class Switch Recombination (epmc).pdf DeepDyve Pubget Overpricing