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10.1016/j.jmb.2014.03.016 http://scihub22266oqcxt.onion/10.1016/j.jmb.2014.03.016 C4177298!4177298!24709417     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24709417.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Mol+Biol 2014 ; 426 (20): 3389-412 Nephropedia Template TP {{tp|p=24709417|t=2014. Epigenetic Signaling in Psychiatric Disorders |pdf=|usr=}}{{24709417}} gab.com Text Epigenetic Signaling in Psychiatric Disorders JO: J Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=24709417 #FOAvip Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in neural circuit structure and function. While genetic factors are important in the etiology of disorders such as depression and addiction, relatively high rates of discordance among identical twins clearly indicate the importance of additional mechanisms. Environmental factors such as stress or prior drug exposure are known to play a role in the onset of these illnesses. Such exposure to environmental insults induces stable changes in gene expression, neural circuit function, and ultimately behavior, and these maladaptations appear distinct between developmental and adult exposures. Increasing evidence indicates that these sustained abnormalities are maintained by epigenetic modifications in specific brain regions. Indeed, transcriptional dysregulation and associated aberrant epigenetic regulation is a unifying theme in psychiatric disorders. Aspects of depression and addiction can be modeled in animals by inducing disease-like states through environmental manipulations (e.g., chronic-stress, drug administration). Understanding how environmental factors recruit the epigenetic machinery in animal models is revealing new insight into disease mechanisms in humans. Twit Text FOAVip Epigenetic Signaling in Psychiatric Disorders ????J Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=24709417 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24709417 #FOAvip English Wikipedia <ref>{{Cite pmid|24709417}}</ref> Epigenetic Signaling in Psychiatric Disorders #MMPMID24709417 Peña CJ; Bagot RC; Labonté B; Nestler EJ J Mol Biol 2014[Oct]; 426 (20): 3389-412 PMID24709417show ga Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in neural circuit structure and function. While genetic factors are important in the etiology of disorders such as depression and addiction, relatively high rates of discordance among identical twins clearly indicate the importance of additional mechanisms. Environmental factors such as stress or prior drug exposure are known to play a role in the onset of these illnesses. Such exposure to environmental insults induces stable changes in gene expression, neural circuit function, and ultimately behavior, and these maladaptations appear distinct between developmental and adult exposures. Increasing evidence indicates that these sustained abnormalities are maintained by epigenetic modifications in specific brain regions. Indeed, transcriptional dysregulation and associated aberrant epigenetic regulation is a unifying theme in psychiatric disorders. Aspects of depression and addiction can be modeled in animals by inducing disease-like states through environmental manipulations (e.g., chronic-stress, drug administration). Understanding how environmental factors recruit the epigenetic machinery in animal models is revealing new insight into disease mechanisms in humans. äEpigenetic Signaling in Psychiatric Disorders (epmc).pdf DeepDyve Pubget Overpricing