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10.1098/rstb.2016.0271

http://scihub22266oqcxt.onion/10.1098/rstb.2016.0271
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C5597738!5597738!28893938
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suck abstract from ncbi


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pmid28893938      Philos+Trans+R+Soc+Lond+B+Biol+Sci 2017 ; 372 (1732): ä
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  • Epstein?Barr virus-associated lymphomas #MMPMID28893938
  • Shannon-Lowe C; Rickinson AB; Bell AI
  • Philos Trans R Soc Lond B Biol Sci 2017[Oct]; 372 (1732): ä PMID28893938show ga
  • Epstein?Barr virus (EBV), originally discovered through its association with Burkitt lymphoma, is now aetiologically linked to a remarkably wide range of lymphoproliferative lesions and malignant lymphomas of B-, T- and NK-cell origin. Some occur as rare accidents of virus persistence in the B lymphoid system, while others arise as a result of viral entry into unnatural target cells. The early finding that EBV is a potent B-cell growth transforming agent hinted at a simple oncogenic mechanism by which this virus could promote lymphomagenesis. In reality, the pathogenesis of EBV-associated lymphomas involves a complex interplay between different patterns of viral gene expression and cellular genetic changes. Here we review recent developments in our understanding of EBV-associated lymphomagenesis in both the immunocompetent and immunocompromised host.This article is part of the themed issue ?Human oncogenic viruses?.
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