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The evolution of neurodegeneration #MMPMID22975006
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Curr Biol 2012[Sep]; 22 (17): R753-61 PMID22975006show ga
There are a number of neurodegenerative diseases that principally affect humans as they age, characterized by the loss of specific groups of neurons in different brain regions. Although these are in general sporadic disorders, it is know clear that many of these diseases have a substantial genetic component. As genes are the raw material with which evolution works, we might benefit from understanding these genes in an evolutionary framework. Here, I will discuss how we can understand whether evolution has shaped genes involved in neurodegeneration and the implications for practical issues such as our choice of model systems for these diseases and more theoretical concerns such as the level of selection against these phenotypes.