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10.1371/journal.pone.0135940 http://scihub22266oqcxt.onion/10.1371/journal.pone.0135940 C4564169!4564169!26352435     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26352435.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2015 ; 10 (9): ä Nephropedia Template TP {{tp|p=26352435|t=2015. Evolutionary History of the Photolyase/Cryptochrome Superfamily in Eukaryotes |pdf=|usr=}}{{26352435}} gab.com Text Evolutionary History of the Photolyase/Cryptochrome Superfamily in Eukaryotes JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26352435 #FOAvip Background: Photolyases and cryptochromes are evolutionarily related flavoproteins, which however perform distinct physiological functions. Photolyases (PHR) are evolutionarily ancient enzymes. They are activated by light and repair DNA damage caused by UV radiation. Although cryptochromes share structural similarity with DNA photolyases, they lack DNA repair activity. Cryptochrome (CRY) is one of the key elements of the circadian system in animals. In plants, CRY acts as a blue light receptor to entrain circadian rhythms, and mediates a variety of light responses, such as the regulation of flowering and seedling growth. Results: We performed a comprehensive evolutionary analysis of the CRY/PHR superfamily. The superfamily consists of 7 major subfamilies: CPD class I and CPD class II photolyases, (6?4) photolyases, CRY-DASH, plant PHR2, plant CRY and animal CRY. Although the whole superfamily evolved primarily under strong purifying selection (average ? = 0.0168), some subfamilies did experience strong episodic positive selection during their evolution. Photolyases were lost in higher animals that suggests natural selection apparently became weaker in the late stage of evolutionary history. The evolutionary time estimates suggested that plant and animal CRYs evolved in the Neoproterozoic Era (~1000?541 Mya), which might be a result of adaptation to the major climate and global light regime changes occurred in that period of the Earth?s geological history. Twit Text FOAVip Evolutionary History of the Photolyase/Cryptochrome Superfamily in Eukaryotes ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26352435 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26352435 #FOAvip English Wikipedia <ref>{{Cite pmid|26352435}}</ref> Evolutionary History of the Photolyase/Cryptochrome Superfamily in Eukaryotes #MMPMID26352435 Mei Q; Dvornyk V PLoS One 2015[]; 10 (9): ä PMID26352435show ga Background: Photolyases and cryptochromes are evolutionarily related flavoproteins, which however perform distinct physiological functions. Photolyases (PHR) are evolutionarily ancient enzymes. They are activated by light and repair DNA damage caused by UV radiation. Although cryptochromes share structural similarity with DNA photolyases, they lack DNA repair activity. Cryptochrome (CRY) is one of the key elements of the circadian system in animals. In plants, CRY acts as a blue light receptor to entrain circadian rhythms, and mediates a variety of light responses, such as the regulation of flowering and seedling growth. Results: We performed a comprehensive evolutionary analysis of the CRY/PHR superfamily. The superfamily consists of 7 major subfamilies: CPD class I and CPD class II photolyases, (6?4) photolyases, CRY-DASH, plant PHR2, plant CRY and animal CRY. Although the whole superfamily evolved primarily under strong purifying selection (average ? = 0.0168), some subfamilies did experience strong episodic positive selection during their evolution. Photolyases were lost in higher animals that suggests natural selection apparently became weaker in the late stage of evolutionary history. The evolutionary time estimates suggested that plant and animal CRYs evolved in the Neoproterozoic Era (~1000?541 Mya), which might be a result of adaptation to the major climate and global light regime changes occurred in that period of the Earth?s geological history. äEvolutionary History of the Photolyase/Cryptochrome Superfamily in Euk(epmc).pdf DeepDyve Pubget Overpricing