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Extracellular vesicles: Emerging targets for cancer therapy #MMPMID24703619
Vader P; Breakefield XO; Wood MJ
Trends Mol Med 2014[Jul]; 20 (7): 385-93 PMID24703619show ga
Extracellular vesicles (EVs), including exosomes, microvesicles and apoptotic bodies, are released by almost all cell types, including tumour cells. Through transfer of their molecular contents, EVs are capable of altering the function of recipient cells. Increasing evidence suggests a key role for EV-mediated intercellular communication in a variety of cellular processes involved in tumour development and progression, including immune suppression, angiogenesis and metastasis. Aspects of EV biogenesis or function are therefore increasingly being considered as targets for anti-cancer therapy. Here, we summarize the current knowledge on the contributions of EVs to cancer pathogenesis and discuss novel therapeutic strategies to target EVs to prevent tumour growth and spread.